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Install R for your operating system from CRAN.
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Install RStudio from RStudio.
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Install CRAN Packages from R console like this:
install.packages(c("pkg1", "pkg2")) install.packages("pkg.zip", repos=NULL)
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Install Bioconductor packages as follows:
source("http://www.bioconductor.org/biocLite.R") library(BiocInstaller) BiocVersion() biocLite() biocLite(c("pkg1", "pkg2"))
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For more details consult the Bioc Install page and BiocInstaller package.